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Search of human proteins with 112789566
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
(839 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 1713 0.0
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 514 e-145
gi|37577159 calcium-sensing receptor [Homo sapiens] 391 e-108
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 379 e-105
gi|112807234 G protein-coupled receptor, family C, group 6, memb... 360 3e-99
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 261 2e-69
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 258 2e-68
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 247 3e-65
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 243 7e-64
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 241 2e-63
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 241 2e-63
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 241 2e-63
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 226 7e-59
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 226 7e-59
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 226 9e-59
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 219 6e-57
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 219 6e-57
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 218 2e-56
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 218 2e-56
gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] 106 8e-23
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ... 63 1e-09
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 48 3e-05
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 45 3e-04
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 45 3e-04
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 45 3e-04
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 42 0.002
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 42 0.002
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 42 0.002
gi|40217833 G protein-coupled receptor family C, group 5, member... 39 0.015
gi|40217831 G protein-coupled receptor family C, group 5, member... 39 0.015
>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
Length = 839
Score = 1713 bits (4437), Expect = 0.0
Identities = 839/839 (100%), Positives = 839/839 (100%)
Query: 1 MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCK 60
MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCK
Sbjct: 1 MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCK 60
Query: 61 EYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDN 120
EYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDN
Sbjct: 61 EYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDN 120
Query: 121 LLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPAL 180
LLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPAL
Sbjct: 121 LLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPAL 180
Query: 181 LRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETL 240
LRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETL
Sbjct: 181 LRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETL 240
Query: 241 PTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIA 300
PTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIA
Sbjct: 241 PTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIA 300
Query: 301 SESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCN 360
SESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCN
Sbjct: 301 SESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCN 360
Query: 361 QECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQL 420
QECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQL
Sbjct: 361 QECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQL 420
Query: 421 LEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQD 480
LEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQD
Sbjct: 421 LEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQD 480
Query: 481 ISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPN 540
ISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPN
Sbjct: 481 ISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPN 540
Query: 541 NEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAG 600
NEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAG
Sbjct: 541 NEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAG 600
Query: 601 GPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFK 660
GPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFK
Sbjct: 601 GPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFK 660
Query: 661 MASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSC 720
MASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSC
Sbjct: 661 MASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSC 720
Query: 721 NPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFM 780
NPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFM
Sbjct: 721 NPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFM 780
Query: 781 SAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD 839
SAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD
Sbjct: 781 SAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD 839
>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
Length = 841
Score = 514 bits (1325), Expect = e-145
Identities = 303/819 (36%), Positives = 436/819 (53%), Gaps = 19/819 (2%)
Query: 26 DFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMC-KEYEVKVIGYNLMQAMRFAVEEINN 84
DF LPGDYLL GLF LH+ + H +V +C + GY+L QAMR VEEINN
Sbjct: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRP--EVTLCDRSCSFNEHGYHLFQAMRLGVEEINN 88
Query: 85 DSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHE-DNLLPIQEDYSNYISRVVAVIGPDN 143
++LLP + LGY++ DVC S NV L L+ + + +Q D +Y V+AVIGPD+
Sbjct: 89 STALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDS 148
Query: 144 SESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRW 203
+ T A LS FL+P I+Y+A S+ L K ++P+ LRT P+ + +E MV L+ F W
Sbjct: 149 TNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGW 208
Query: 204 NWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDK 263
WI ++ SSD YG+ Q L + + ICIAF++ +P +R+ ++
Sbjct: 209 TWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPF------SAQVGDERMQCLMRH 262
Query: 264 LQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFL 323
L Q+ A VVVVFS FF V+ N TG VW+ASE+WA+ + + ++ +G L
Sbjct: 263 LAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVL 322
Query: 324 GITIQSVPIPGFSEFREWGPQA---GPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLS 380
G+ IQ +PG F E +A P P + S + NQ C C L+
Sbjct: 323 GVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWC-SSNQLCRECQAFMAHTMPKLKAF 381
Query: 381 GERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDP 440
Y+ Y AVYAVAH LH LLGC C++ VYPWQLLE+I KV+F L + F+
Sbjct: 382 SMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQLLEQIHKVHFLLHKDTVAFND 441
Query: 441 QGDVALHLEIVQWQWDRSQNPFQSVAS--YYPLQRQLKNIQDISWHTINNTIPMSMCSKR 498
D I+ W W+ + F + S + P+Q + N I WH +N +P S+CS
Sbjct: 442 NRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNI-NETKIQWHGKDNQVPKSVCSSD 500
Query: 499 CQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVF 558
C G ++ G H CCFEC+ C GTFLN + D Y CQ C EW+ + +CF R +VF
Sbjct: 501 CLEGHQRVVTGFHHCCFECVPCGAGTFLNKS-DLYRCQPCGKEEWAPEGSQTCFPRTVVF 559
Query: 559 LEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVV 618
L E + + L L L +F H TP+VRSAGG +CFLML L +
Sbjct: 560 LALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSL 619
Query: 619 PVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGP 678
+ G P CL RQALF L FTI +SC+ VRSFQ++ FK +++ P Y WV+ G
Sbjct: 620 YGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGA 679
Query: 679 YVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLL 738
+ + + +++I + ++ P R P + ++ C + + LL
Sbjct: 680 GLFVMISSAAQLLICLTWLVVWTPLP-AREYQRFPHLVMLECTETNSLGFILAFLYNGLL 738
Query: 739 SVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVL 798
S+ F+ +Y+GK+LP NYNEAK +T S+ F F S ++ T S Y G + +++ +
Sbjct: 739 SISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGLS 798
Query: 799 NLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMR 837
+L + GYF PKCY+IL P+ N+ +F + IQ YT R
Sbjct: 799 SLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRR 837
>gi|37577159 calcium-sensing receptor [Homo sapiens]
Length = 1078
Score = 391 bits (1005), Expect = e-108
Identities = 266/877 (30%), Positives = 431/877 (49%), Gaps = 85/877 (9%)
Query: 16 WVLAEPAENSDFYLP-------GDYLLGGLFSLHANM--KGIVHLNFLQVPMCKEYEVKV 66
WVL ++ Y P GD +LGGLF +H + K + + C Y +
Sbjct: 8 WVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFR- 66
Query: 67 IGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCY-ISNNVQPVLYFLAHED-NLLPI 124
G+ +QAM FA+EEIN+ +LLP + LGY I D C +S ++ L F+A + L +
Sbjct: 67 -GFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNL 125
Query: 125 QE--DYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLR 182
E + S +I +AV+G S VAN L LF +PQ++Y++ S L +K +F + LR
Sbjct: 126 DEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLR 185
Query: 183 TTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPT 242
T P+ +H AM ++ +FRWNW+ + + D YGR + E RDICI F E +
Sbjct: 186 TIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELI-- 243
Query: 243 LQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASE 302
+Q EE Q +V ++ Q STA+V+VVFS L E++R+N TG +W+ASE
Sbjct: 244 ---SQYSDEEEIQHVVEVI---QNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASE 297
Query: 303 SWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEF---------------REWGPQA-- 345
+WA ++ +G +G +++ IPGF EF +E+ +
Sbjct: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357
Query: 346 --------GPPPLSRTSQSYTCNQECDNCLNATLSFNTI--------------LRLSGER 383
GP P+ + + + D N++ +F + + + R
Sbjct: 358 CHLQEGAKGPLPVDTFLRGH--EESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLR 415
Query: 384 VVYSVYSAVYAVAHALHSLLGC--------DKSTCTKRVVYPWQLLEEIWKVNFTL-LDH 434
+ Y+VY AVY++AHAL + C + S + V WQ+L+ + +NFT +
Sbjct: 416 ISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGE 475
Query: 435 QIFFDPQGDVALHLEIVQWQWDRSQNP--FQSVASYYPL----QRQLKNIQDISWHTINN 488
Q+ FD GD+ + I+ W F+ V Y +R N + I W +
Sbjct: 476 QVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSR 535
Query: 489 TIPMSMCSKRCQSGQKKKPV-GIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQS 547
+P S CS+ C +G +K + G CCFEC++C G + + T D C CP++ WS ++
Sbjct: 536 EVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDET-DASACNKCPDDFWSNEN 594
Query: 548 ETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLM 607
TSC +++ FL W E IA+ L A LG T +L +F + TPIV++ + +L+
Sbjct: 595 HTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLL 654
Query: 608 LTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPR 667
L LL + ++G P+ TC RQ F + F +CISCI V++ +++ F+ ++ P
Sbjct: 655 LFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFE--AKIPT 712
Query: 668 AY-SYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRN 726
++ W ++ + T +++VI VI L T + R + +I ++C+
Sbjct: 713 SFHRKWWGLNLQFLLVFLCTFMQIVICVI-WLYTAPPSSYRNQELEDEIIFITCHEGSLM 771
Query: 727 SLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGV 786
+L F LL+ + F FA+ ++LP N+NEAKFIT SM +F +S ++ G
Sbjct: 772 ALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGK 831
Query: 787 LVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNT 823
V+ V+++ + + F K Y+ILF P RNT
Sbjct: 832 FVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNT 868
>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
Length = 852
Score = 379 bits (974), Expect = e-105
Identities = 254/835 (30%), Positives = 405/835 (48%), Gaps = 38/835 (4%)
Query: 15 LWVLAEPAENSDFYLP------GDYLLGGLFSL-HANMKGIVHLNFLQVPMCKEYEVKVI 67
LW L P + L GDY+LGGLF L A G+ P+C + +
Sbjct: 11 LWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGL 70
Query: 68 GYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNV---QPVLYFLAHEDNL-LP 123
+ L AM+ AVEEINN S LLPG+ LGY++ D C S V +P L FLA + +
Sbjct: 71 LWAL--AMKMAVEEINNKSDLLPGLRLGYDLFDTC--SEPVVAMKPSLMFLAKAGSRDIA 126
Query: 124 IQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRT 183
+Y+ Y RV+AVIGP +SE M F S FL+PQ++Y A + L + FP+ RT
Sbjct: 127 AYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRT 186
Query: 184 TPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTL 243
PS + A +L+ F WNW+ L S D YGR + A R ICIA + +P
Sbjct: 187 VPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLP 246
Query: 244 QPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASES 303
+ + + ++ ++ ++ QS+ +VV++F+ + FN + + VW+ASE+
Sbjct: 247 RADDSRLG----KVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEA 302
Query: 304 WAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPP-----LSRTSQSY- 357
W ++ L + +GT LG + + F ++ + P L Q
Sbjct: 303 WLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQGLE 362
Query: 358 --TCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTC-TKRV 414
Q C C TL N L+ + +SVY+AVY+VA ALH+ L C+ S C +
Sbjct: 363 EDVVGQRCPQCDCITLQ-NVSAGLNHHQ-TFSVYAAVYSVAQALHNTLQCNASGCPAQDP 420
Query: 415 VYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQ 474
V PWQLLE ++ + F + + FD G+V + ++ W W S V + R
Sbjct: 421 VKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRT 480
Query: 475 LKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYE 534
+ I WHT +N P+S CS++CQ GQ ++ G H CC++C+DC G++ D+
Sbjct: 481 ER--LKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSY-RQNPDDIA 537
Query: 535 CQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTP 594
C C +EWS + T CF+R+ FL W E + + LL +L LA L +F H +P
Sbjct: 538 CTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSP 597
Query: 595 IVRSAGGPM-CFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSF 653
+V+++GGP+ CF ++ L LV V+ ++ G P + CL +Q L L T C+S + +++
Sbjct: 598 LVQASGGPLACFGLVCLGLVCLSVL-LFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAA 656
Query: 654 QIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDD- 712
+I ++ + S +R GP+ + + + + + + P TD
Sbjct: 657 EIFVESELPLSWADRLSGCLR--GPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHML 714
Query: 713 PKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTS 772
P +V C S + + L+ + F ++ + P YN A+ +T +M YF +
Sbjct: 715 PTEALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGRYNRARGLTFAMLAYFIT 774
Query: 773 SVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYF 827
VS ++ VL V + +L +L I + P+CY+++ P NTP +F
Sbjct: 775 WVSFVPLLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFF 829
>gi|112807234 G protein-coupled receptor, family C, group 6, member
A [Homo sapiens]
Length = 926
Score = 360 bits (924), Expect = 3e-99
Identities = 255/867 (29%), Positives = 421/867 (48%), Gaps = 63/867 (7%)
Query: 12 FFLLWVLAEPAENSDFYL----PGDYLLGGLFSLHANMKGIVHL-NFLQVPMCKEYEVKV 66
F ++ ++P + D ++ PG ++GGLF++H M Q+ C +E+ V
Sbjct: 11 FVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISV 70
Query: 67 IGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCY-ISNNVQPVLYFLAHED---NLL 122
L AM ++E INN S+LLPGV LGYEI D C ++ + L FL+ + +
Sbjct: 71 FLQTL--AMIHSIEMINN-STLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETV 127
Query: 123 PIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLR 182
+ DYS+Y+ RV AVIG SE M V+ L+L L+PQ+ Y + ++ L DK+RFP+ LR
Sbjct: 128 EFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLR 187
Query: 183 TTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPT 242
T PS H I+AM L+ WNWI ++ + D YGR + ++CIAF+E LP
Sbjct: 188 TVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPA 247
Query: 243 LQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASE 302
+ + + L I+ + Q V+VVF ++ FN+ + N +WIAS+
Sbjct: 248 FLSDNTIEVRINRTLKKIILEAQ---VNVIVVFLRQFHVFDLFNKAIEMNI-NKMWIASD 303
Query: 303 SWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFRE---WGPQAGPPPLSR-----TS 354
+W+ + + ++ +G +G + I F F + P L ++
Sbjct: 304 NWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSA 363
Query: 355 QSYTCNQECDNCL------------NATLSFNTILR------LSGERVVYSVYSAVYAVA 396
+Y + + C+ N + N ++R + +++S+ AV+A+
Sbjct: 364 CAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALG 423
Query: 397 HALHSLLGCDKSTC-TKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQW 455
+A+ L C C PW+LL + V FT + FD GD+ ++V W+
Sbjct: 424 YAIRDL--CQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKE 481
Query: 456 DRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIP--MSMCSKRCQSGQKKKPV-GIHV 512
+A Y LQ + I D + S CSK C GQ KK H+
Sbjct: 482 INGHMTVTKMAE-YDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI 540
Query: 513 CCFECIDCLPGTFLNHTEDEYECQACPN-NEWSYQSETSCFKRQLVFLEWHEAPTIAVAL 571
CC+EC +C + N T D C C N W+ T CF++++ +L W+++ I + +
Sbjct: 541 CCYECQNCPENHYTNQT-DMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLI 599
Query: 572 LAALGFLSTLAILVIFWRHFQTPIVRSAGG-PMCFLMLTLLLVAYMVVPVYVGPPKVSTC 630
L+ LG + L + +IF R+ TP+V+S+GG +C+++L + + ++G P+ TC
Sbjct: 600 LSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTC 659
Query: 631 LCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKM 690
RQ +F + FT+CISCI +S +I+ AF S P+ + P + + T +++
Sbjct: 660 KTRQTMFGVSFTLCISCILTKSLKILLAF---SFDPKLQKFLKCLYRPILIIFTCTGIQV 716
Query: 691 VIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLD--LLLSVVGFSFAYM 748
VI + ++ +PT + P++ I+ C + L F T L +L+ + F FA+
Sbjct: 717 VICTLWLIFA--APTVEVNVSLPRVIILECEEG--SILAFGTMLGYIAILAFICFIFAFK 772
Query: 749 GKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLGYF 808
GK NYNEAKFIT M YF + ++ + G V V+++V +++ I F
Sbjct: 773 GKY--ENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTF 830
Query: 809 GPKCYMILFYPERNTPAYFNSMIQGYT 835
PKCY+I+ E NT + F MI Y+
Sbjct: 831 IPKCYVIICKQEINTKSAFLKMIYSYS 857
>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
Length = 587
Score = 261 bits (666), Expect = 2e-69
Identities = 148/420 (35%), Positives = 220/420 (52%), Gaps = 5/420 (1%)
Query: 420 LLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVAS--YYPLQRQLKN 477
LLE+I KV+F L + F+ D I+ W W+ + F + S + P+Q + N
Sbjct: 167 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNI-N 225
Query: 478 IQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQA 537
I WH +N +P S+CS C G ++ G H CCFEC+ C GTFLN + D Y CQ
Sbjct: 226 ETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKS-DLYRCQP 284
Query: 538 CPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVR 597
C EW+ + +CF R +VFL E + + L L L +F H TP+VR
Sbjct: 285 CGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVR 344
Query: 598 SAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVC 657
SAGG +CFLML L + + G P CL RQALF L FTI +SC+ VRSFQ++
Sbjct: 345 SAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLII 404
Query: 658 AFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITI 717
FK +++ P Y WV+ G + + + +++I + ++ P R P + +
Sbjct: 405 IFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLP-AREYQRFPHLVM 463
Query: 718 VSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLC 777
+ C + + LLS+ F+ +Y+GK+LP NYNEAK +T S+ F F S ++
Sbjct: 464 LECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFF 523
Query: 778 TFMSAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMR 837
T S Y G + +++ + +L + GYF PKCY+IL P+ N+ +F + IQ YT R
Sbjct: 524 TTASVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRR 583
Score = 106 bits (265), Expect = 8e-23
Identities = 72/195 (36%), Positives = 100/195 (51%), Gaps = 13/195 (6%)
Query: 26 DFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMC-KEYEVKVIGYNLMQAMRFAVEEINN 84
DF LPGDYLL GLF LH+ + H +V +C + GY+L QAMR VEEINN
Sbjct: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRP--EVTLCDRSCSFNEHGYHLFQAMRLGVEEINN 88
Query: 85 DSSLLPGVLLGYEIVDVCYISNNVQPVLYFLA-HEDNLLPIQEDYSNYISRVVAVIGPDN 143
++LLP + LGY++ DVC S NV L L+ + + +Q D +Y V+AVIGPD+
Sbjct: 89 STALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDS 148
Query: 144 SESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRW 203
+ T A LS FL+P + E KV F T D+ ++ + W
Sbjct: 149 TNRAATTAALLSPFLVPMLL------EQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDW 202
Query: 204 N---WIIVLVSSDTY 215
N W ++ S T+
Sbjct: 203 NGPKWTFTVLGSSTW 217
>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
Length = 480
Score = 258 bits (659), Expect = 2e-68
Identities = 155/399 (38%), Positives = 216/399 (54%), Gaps = 14/399 (3%)
Query: 26 DFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMC-KEYEVKVIGYNLMQAMRFAVEEINN 84
DF LPGDYLL GLF LH+ + H +V +C + GY+L QAMR VEEINN
Sbjct: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRP--EVTLCDRSCSFNEHGYHLFQAMRLGVEEINN 88
Query: 85 DSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHE-DNLLPIQEDYSNYISRVVAVIGPDN 143
++LLP + LGY++ DVC S NV L L+ + + +Q D +Y V+AVIGPD+
Sbjct: 89 STALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDS 148
Query: 144 SESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRW 203
+ T A LS FL+P I+Y+A S+ L K ++P+ LRT P+ + +E MV L+ F W
Sbjct: 149 TNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGW 208
Query: 204 NWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDK 263
WI ++ SSD YG+ Q L + + ICIAF++ +P +R+ ++
Sbjct: 209 TWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPF------SAQVGDERMQCLMRH 262
Query: 264 LQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFL 323
L Q+ A VVVVFS FF V+ N TG VW+ASE+WA+ + + ++ +G L
Sbjct: 263 LAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVL 322
Query: 324 GITIQSVPIPGFSEFREWGPQA---GPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLS 380
G+ IQ +PG F E +A P P + S + NQ C C L+
Sbjct: 323 GVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWC-SSNQLCRECQAFMAHTMPKLKAF 381
Query: 381 GERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQ 419
Y+ Y AVYAVAH LH LLGC C++ VYPWQ
Sbjct: 382 SMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
Length = 879
Score = 247 bits (631), Expect = 3e-65
Identities = 211/837 (25%), Positives = 360/837 (43%), Gaps = 81/837 (9%)
Query: 29 LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSL 88
+ GD +LGGLF ++ G + G ++AM FA++EIN D L
Sbjct: 35 IEGDLVLGGLFPINEKGTGTEECGRINEDR---------GIQRLEAMLFAIDEINKDDYL 85
Query: 89 LPGVLLGYEIVDVCY-----ISNNVQPVLYFLAHEDNLLPIQEDYSNYISR-----VVAV 138
LPGV LG I+D C + +++ V L D + D S I + V
Sbjct: 86 LPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGV 145
Query: 139 IGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLM 198
IG S + VAN L LF +PQI+Y++ S +L DK R+ RT P + +AM +++
Sbjct: 146 IGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEIL 205
Query: 199 LHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLV 258
F W ++ + S YG + + R+ICIA E + ++ S
Sbjct: 206 RFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDS------- 258
Query: 259 TIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRH 318
I + LQ+ ARVVV+F R N W+AS+ W + +E
Sbjct: 259 VIRELLQKPNARVVVLFMRSDDSRELIAAASRAN-ASFTWVASDGWGAQESIIKGSEHVA 317
Query: 319 LGTFLGITIQSVPIPGFSEFRE----WGPQAGPPPLSRTSQSYTCNQE--------CDNC 366
G + + + S P+ F + + + P Q + C+ + CD
Sbjct: 318 YGA-ITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKH 376
Query: 367 LNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLG--CDKST--CTKRVVYPWQLL- 421
L S E + V +AVYA+AHALH + C +T C + + L
Sbjct: 377 LAIDSS-----NYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLY 431
Query: 422 -EEIWKVNFTL-------LDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQR 473
+ + K+NFT D + FD GD + +Q + + V +
Sbjct: 432 KDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHW----A 487
Query: 474 QLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEY 533
+ ++ S H N++P S CS C + K VCC+ CI C P +L DE+
Sbjct: 488 ETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL---ADEF 544
Query: 534 ECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQT 593
C C + +W T C+ ++ W +A I +A LGF+ T ++ +F +H T
Sbjct: 545 TCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNT 604
Query: 594 PIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSF 653
P+V+++G +C+++L + ++Y + ++ P C R+ F IC S + ++
Sbjct: 605 PLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTN 664
Query: 654 QIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDP 713
I F + + ++ + I V ++V+V + ++ T +
Sbjct: 665 CIARIFDGVKNGAQRPKFISPSSQVFICLGLILV-QIVMVSVWLILEAPGTRRYTLAEKR 723
Query: 714 KITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSS 773
+ I+ CN +S+L + + D++L ++ +A+ ++ P N+NEAKFI +M +T+
Sbjct: 724 ETVILKCNVK-DSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTM---YTTC 779
Query: 774 VSLCTFMSAYSGVLVTIVDLLV-TVLNLLAISLG-------YFGPKCYMILFYPERN 822
+ F+ + VT D V T +++SL F PK ++ILF P++N
Sbjct: 780 IIWLAFLPIF---YVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKN 833
>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
[Homo sapiens]
Length = 872
Score = 243 bits (619), Expect = 7e-64
Identities = 229/856 (26%), Positives = 387/856 (45%), Gaps = 82/856 (9%)
Query: 14 LLW-VLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLM 72
LLW +AE L GD +LGGLF +H KG + V E+ G +
Sbjct: 12 LLWGAVAEGPAKKVLTLEGDLVLGGLFPVH--QKGGPAEDCGPV---NEHR----GIQRL 62
Query: 73 QAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYI 132
+AM FA++ IN D LLPGV LG I+D C S + + L L D S +I
Sbjct: 63 EAMLFALDRINRDPHLLPGVRLGAHILDSC--SKDTHALEQALDFVRASLSRGADGSRHI 120
Query: 133 -------------SRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPA 179
+ + VIG S+ + VAN L LF +PQI+Y++ S +L DK R+
Sbjct: 121 CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 180
Query: 180 LLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQET 239
RT P +AM +++ F W ++ + S YG + R+IC+A E
Sbjct: 181 FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK 240
Query: 240 LPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVF--SPDLTLYHFFNEVLRQNFTGAV 297
+ + M+ + +V + LQ+ +ARV V+F S D ++ L +FT
Sbjct: 241 V-----GRAMSRAAFEGVVRAL--LQKPSARVAVLFTRSEDARELLAASQRLNASFT--- 290
Query: 298 WIASESW-AIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFRE----WGPQAGPPPLSR 352
W+AS+ W A++ V+ +E G + I + S PI F+ + + W P
Sbjct: 291 WVASDGWGALESVVAG-SEGAAEGA-ITIELASYPISDFASYFQSLDPWNNSRNPWFREF 348
Query: 353 TSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLG--CDKST- 409
Q + C+ +C +L + E + V +AVYA+AHALH++ C +T
Sbjct: 349 WEQRFRCSFRQRDCAAHSLR---AVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTR 405
Query: 410 -------CTKRVVYPWQLLEEIWKVNFTLLD--HQIFFDPQGDVALHLEIVQW-QWDRSQ 459
R +Y +L + F D +++ FD GD I + + +
Sbjct: 406 LCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGR 465
Query: 460 NPFQSVASYYPLQRQLKNIQDISWHTIN-NTIPMSMCSKRCQSGQKKKPVGIHVCCFECI 518
+Q V Y + + I W + + +P S CS+ C + K VCC+ CI
Sbjct: 466 YRYQKVG--YWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCI 523
Query: 519 DCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFL 578
C P + DE+ C C W S T CF+ ++ W +A + +A LG L
Sbjct: 524 PCQP---YEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGAL 580
Query: 579 STLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFP 638
+TL +L +F RH TP+V+++G +C+++L + + Y + +++ P + C R+
Sbjct: 581 ATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLG 640
Query: 639 LCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVL---KMVIVVI 695
F++C S + ++ +I F A R + R+ P +A L +++IVV
Sbjct: 641 TAFSVCYSALLTKTNRIARIFGGA----REGAQRPRFISPASQVAICLALISGQLLIVVA 696
Query: 696 GMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTN 755
++ T P+ ++ + CN + S+L + + ++LL + +A+ ++ P N
Sbjct: 697 WLVVEAPGTGKETAPERREVVTLRCN-HRDASMLGSLAYNVLLIALCTLYAFKTRKCPEN 755
Query: 756 YNEAKFITLSMTFYFTSSVSLCTFMSAY----SGVLVTIVDLLVTVLNLLAISLG-YFGP 810
+NEAKFI +M +T+ + F+ + S V + V+V ++ LG F P
Sbjct: 756 FNEAKFIGFTM---YTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAP 812
Query: 811 KCYMILFYPERNTPAY 826
K ++ILF P++N ++
Sbjct: 813 KLHIILFQPQKNVVSH 828
>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
Length = 912
Score = 241 bits (616), Expect = 2e-63
Identities = 223/851 (26%), Positives = 381/851 (44%), Gaps = 96/851 (11%)
Query: 29 LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSL 88
+ GD LGGLF +H + C E + K G + ++AM FA++ INND L
Sbjct: 45 IDGDITLGGLFPVHGRGS--------EGKPCGELK-KEKGIHRLEAMLFALDRINNDPDL 95
Query: 89 LPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYI------------SRVV 136
LP + LG I+D C S + + L L I++D + RVV
Sbjct: 96 LPNITLGARILDTC--SRDTHALEQSLTFVQAL--IEKDGTEVRCGSGGPPIITKPERVV 151
Query: 137 AVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQ 196
VIG S + VAN L LF +PQI+Y++ + +L D R+ R PS + +AMV
Sbjct: 152 GVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVD 211
Query: 197 LMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRD--ICIAFQETLPTLQPNQNMTSEER 254
++ +WN++ + S +YG + ++ +R D +CIA +P +P +
Sbjct: 212 IVRALKWNYVSTVASEGSYGESGVEAFIQK-SREDGGVCIAQSVKIPR-EPKAGEFDKII 269
Query: 255 QRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAV-WIASESWA--IDPVLH 311
+RL L+ S AR V++F+ + + R N TG W+ S+SW I PVLH
Sbjct: 270 RRL------LETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLH 323
Query: 312 NLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATL 371
L E+ + I + + + GF + ++ + N C +A
Sbjct: 324 -LEEVAEGA--VTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALK 380
Query: 372 SFNTILRLSG-ERV-----------VYSVYSAVYAVAHALHSLLGCDKSTCTKRV----- 414
+ + + + ER+ V V AVYA+ HALH++ + C RV
Sbjct: 381 KGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAM---HRDLCPGRVGLCPR 437
Query: 415 ---VYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYP 470
V QLL+ I VNF+ + + + F+ GD +I Q+Q ++ + S+
Sbjct: 438 MDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSW-- 495
Query: 471 LQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTE 530
I+ + W +P S+CS CQ G++KK V CC+ C C T +
Sbjct: 496 TDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPC---TGYQYQV 552
Query: 531 DEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRH 590
D Y C+ CP + ++ T C ++ LEW + LA +G +TL +++ F R+
Sbjct: 553 DRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRY 612
Query: 591 FQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAV 650
TPIV+++G + +++L + + Y + + P + TC R+ L +I + +
Sbjct: 613 NDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLT 672
Query: 651 RSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDP 710
++ +I F+ R A R+ P +A IT + + ++G+ + + +
Sbjct: 673 KTNRIYRIFEQGKRSVSA----PRFISPASQLA-ITFSLISLQLLGICVWFVVDPSHSVV 727
Query: 711 D-------DPKIT--IVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKF 761
D DP+ ++ C+ + SL+ +LL V +A + +P +NEAK
Sbjct: 728 DFQDQRTLDPRFARGVLKCDIS-DLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKP 786
Query: 762 ITLSMTFYFTSSVSLCTFMSAYSG-------VLVTIVDLLVTVLNLLAISLG-YFGPKCY 813
I +M +T+ + F+ + G + + L V+V ++SLG + PK Y
Sbjct: 787 IGFTM---YTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVY 843
Query: 814 MILFYPERNTP 824
+ILF+PE+N P
Sbjct: 844 IILFHPEQNVP 854
>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
[Homo sapiens]
Length = 922
Score = 241 bits (615), Expect = 2e-63
Identities = 233/874 (26%), Positives = 384/874 (43%), Gaps = 107/874 (12%)
Query: 14 LLWVLAEPAENSDFYLP------GDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVI 67
LL LA A + Y P GD LGGLF +HA V ++ +
Sbjct: 24 LLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIK---------REN 74
Query: 68 GYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQED 127
G + ++AM +A+++IN+D +LLP V LG I+D C S + + L L IQ+D
Sbjct: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTC--SRDTYALEQSLTFVQAL--IQKD 130
Query: 128 YSNYI------------SRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKV 175
S+ +VV VIG S + VAN L LF +PQI+Y++ + EL D
Sbjct: 131 TSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDR 190
Query: 176 RFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARR--DIC 233
R+ R P +AMV ++ WN++ L S +YG + G ++++ +C
Sbjct: 191 RYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYG-EKGVESFTQISKEAGGLC 249
Query: 234 IAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNF 293
IA +P + ++ + + I L +R VV+F+ D + R +
Sbjct: 250 IAQSVRIPQERKDRTIDFDR-----IIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQ 304
Query: 294 TGA-VWIASESWA--IDPVLHNLTELRHLGTFLGITIQS--VPIPGFSEFREWGPQAGPP 348
G +W+ S+SW I+P LH ++ ITIQ + GF +
Sbjct: 305 VGHFLWVGSDSWGSKINP-LHQHEDIAEGA----ITIQPKRATVEGFDAYFTSRTLENNR 359
Query: 349 PLSRTSQSYTCNQECDNCLNATLSFNTILRLSG-ERV-----------VYSVYSAVYAVA 396
++ + N C ++ + +T + +G ER+ V V AVYA+A
Sbjct: 360 RNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMA 419
Query: 397 HALHSLLGCDKSTCTK-RVVYPW-------QLLEEIWKVNFT-LLDHQIFFDPQGDVALH 447
HALH + +K C R V P +LL+ I VNF + F+ GD
Sbjct: 420 HALHHM---NKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGR 476
Query: 448 LEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKP 507
+I Q+Q + NP + + + QL NI+D+ W IP S+C+ C+ GQ+KK
Sbjct: 477 YDIFQYQTTNTSNPGYRLIGQWTDELQL-NIEDMQWGKGVREIPASVCTLPCKPGQRKKT 535
Query: 508 VGIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTI 567
CC+ C C + DE CQ CP ++ ++ T C ++ LEWH +
Sbjct: 536 QKGTPCCWTCEPC---DGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAV 592
Query: 568 AVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKV 627
LA LG ++T+ ++ F R+ TPIVR++G + +++LT + + Y++ + + P V
Sbjct: 593 IPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDV 652
Query: 628 STCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITV 687
+ C R+ L I + + ++ +I F+ + A R P +A +
Sbjct: 653 AVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTA----PRLISPTSQLAITSS 708
Query: 688 LKMVIVVIGMLATGLS-PTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDL---------- 736
L V ++ + G+ P D D+ K + NP +L DL
Sbjct: 709 LISVQLLGVFIWFGVDPPNIIIDYDEHK----TMNPEQARGVLKCDITDLQIICSLGYSI 764
Query: 737 LLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVT 796
LL V +A + +P N+NEAK I +M +T+ + F+ + G + L +
Sbjct: 765 LLMVTCTVYAIKTRGVPENFNEAKPIGFTM---YTTCIVWLAFIPIFFGTAQSAEKLYIQ 821
Query: 797 VLNL-------LAISLG-YFGPKCYMILFYPERN 822
L +++LG + PK Y+I+F+PE N
Sbjct: 822 TTTLTISMNLSASVALGMLYMPKVYIIIFHPELN 855
>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
[Homo sapiens]
Length = 915
Score = 241 bits (615), Expect = 2e-63
Identities = 233/874 (26%), Positives = 384/874 (43%), Gaps = 107/874 (12%)
Query: 14 LLWVLAEPAENSDFYLP------GDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVI 67
LL LA A + Y P GD LGGLF +HA V ++ +
Sbjct: 24 LLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIK---------REN 74
Query: 68 GYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQED 127
G + ++AM +A+++IN+D +LLP V LG I+D C S + + L L IQ+D
Sbjct: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTC--SRDTYALEQSLTFVQAL--IQKD 130
Query: 128 YSNYI------------SRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKV 175
S+ +VV VIG S + VAN L LF +PQI+Y++ + EL D
Sbjct: 131 TSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDR 190
Query: 176 RFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARR--DIC 233
R+ R P +AMV ++ WN++ L S +YG + G ++++ +C
Sbjct: 191 RYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYG-EKGVESFTQISKEAGGLC 249
Query: 234 IAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNF 293
IA +P + ++ + + I L +R VV+F+ D + R +
Sbjct: 250 IAQSVRIPQERKDRTIDFDR-----IIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQ 304
Query: 294 TGA-VWIASESWA--IDPVLHNLTELRHLGTFLGITIQS--VPIPGFSEFREWGPQAGPP 348
G +W+ S+SW I+P LH ++ ITIQ + GF +
Sbjct: 305 VGHFLWVGSDSWGSKINP-LHQHEDIAEGA----ITIQPKRATVEGFDAYFTSRTLENNR 359
Query: 349 PLSRTSQSYTCNQECDNCLNATLSFNTILRLSG-ERV-----------VYSVYSAVYAVA 396
++ + N C ++ + +T + +G ER+ V V AVYA+A
Sbjct: 360 RNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMA 419
Query: 397 HALHSLLGCDKSTCTK-RVVYPW-------QLLEEIWKVNFT-LLDHQIFFDPQGDVALH 447
HALH + +K C R V P +LL+ I VNF + F+ GD
Sbjct: 420 HALHHM---NKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGR 476
Query: 448 LEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKP 507
+I Q+Q + NP + + + QL NI+D+ W IP S+C+ C+ GQ+KK
Sbjct: 477 YDIFQYQTTNTSNPGYRLIGQWTDELQL-NIEDMQWGKGVREIPASVCTLPCKPGQRKKT 535
Query: 508 VGIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTI 567
CC+ C C + DE CQ CP ++ ++ T C ++ LEWH +
Sbjct: 536 QKGTPCCWTCEPC---DGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAV 592
Query: 568 AVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKV 627
LA LG ++T+ ++ F R+ TPIVR++G + +++LT + + Y++ + + P V
Sbjct: 593 IPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDV 652
Query: 628 STCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITV 687
+ C R+ L I + + ++ +I F+ + A R P +A +
Sbjct: 653 AVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTA----PRLISPTSQLAITSS 708
Query: 688 LKMVIVVIGMLATGLS-PTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDL---------- 736
L V ++ + G+ P D D+ K + NP +L DL
Sbjct: 709 LISVQLLGVFIWFGVDPPNIIIDYDEHK----TMNPEQARGVLKCDITDLQIICSLGYSI 764
Query: 737 LLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVT 796
LL V +A + +P N+NEAK I +M +T+ + F+ + G + L +
Sbjct: 765 LLMVTCTVYAIKTRGVPENFNEAKPIGFTM---YTTCIVWLAFIPIFFGTAQSAEKLYIQ 821
Query: 797 VLNL-------LAISLG-YFGPKCYMILFYPERN 822
L +++LG + PK Y+I+F+PE N
Sbjct: 822 TTTLTISMNLSASVALGMLYMPKVYIIIFHPELN 855
>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
[Homo sapiens]
Length = 1212
Score = 226 bits (576), Expect = 7e-59
Identities = 218/852 (25%), Positives = 377/852 (44%), Gaps = 92/852 (10%)
Query: 28 YLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKV------IGYNLMQAMRFAVEE 81
++PGD ++G LFS+H Q + K +E K G ++AM +E
Sbjct: 30 HMPGDIIIGALFSVHH-----------QPTVDKVHERKCGAVREQYGIQRVEAMLHTLER 78
Query: 82 INNDSSLLPGVLLGYEIVDVCYISN-NVQPVLYFLAHEDNLLPIQEDY----------SN 130
IN+D +LLP + LG EI D C+ S ++ + F+ D+L+ +E+ S+
Sbjct: 79 INSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFI--RDSLISSEEEEGLVRCVDGSSSS 136
Query: 131 YISR--VVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSAD 188
+ S+ +V VIGP +S + V N L LF +PQI YSA S +L DK F +R PS
Sbjct: 137 FRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDA 196
Query: 189 HHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQN 248
AMV ++ + W ++ + + YG + + A+ ICIA + + Q+
Sbjct: 197 QQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQS 256
Query: 249 MTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGA-VWIASESWAID 307
+ ++L + + K ARVV F +T+ + R G + + S+ WA
Sbjct: 257 F-DKLLKKLTSHLPK-----ARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWA-- 308
Query: 308 PVLHNLTELRHLGTFLGITI--QSVPI------------------PGFSEFREWGPQAGP 347
+++T+ GITI QS + P F EF + Q
Sbjct: 309 -DRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRL 367
Query: 348 PPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDK 407
+ + Y N+ C++ L TL + + V+ ++YS Y + + SL
Sbjct: 368 EGFPQENSKY--NKTCNSSL--TLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYA 423
Query: 408 STC-TKRVVYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQW-QWDRSQNPFQS 464
C + + +LLE + K NFT + I FD GD EI+ + + + + +
Sbjct: 424 GLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYIN 483
Query: 465 VASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQ-KKKPVGIHVCCFECIDCLPG 523
V S+ +LK D W +N I S+CS+ C+ GQ K G CC+ C C
Sbjct: 484 VGSWD--NGELKMDDDEVWSKKSNII-RSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN 540
Query: 524 TFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAI 583
++ DEY C+AC W T C + +L W + IA + A LG L+TL +
Sbjct: 541 EYV---FDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFV 597
Query: 584 LVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTI 643
V+F + TP+V+S+ +C+++L + + Y+ + PK C ++ L +
Sbjct: 598 TVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAM 657
Query: 644 CISCIAVRSFQIVCAF-----KMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGML 698
S + ++ +I K+ ++ PR S + + +AFI + + +++ +
Sbjct: 658 SYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQ-----LVIAFILICIQLGIIVALF 712
Query: 699 ATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNE 758
P ++ ++ CN ++ + LL + +A+ + +P N+NE
Sbjct: 713 IMEPPDIMHDYPSIREVYLI-CNTT-NLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNE 770
Query: 759 AKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLG-YFGPKCYMILF 817
AK+I +M +T+ + F+ Y G I+ + +V ++LG F PK Y+IL
Sbjct: 771 AKYIAFTM---YTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILA 827
Query: 818 YPERNTPAYFNS 829
PERN + F +
Sbjct: 828 KPERNVRSAFTT 839
>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
[Homo sapiens]
Length = 1180
Score = 226 bits (576), Expect = 7e-59
Identities = 218/852 (25%), Positives = 377/852 (44%), Gaps = 92/852 (10%)
Query: 28 YLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKV------IGYNLMQAMRFAVEE 81
++PGD ++G LFS+H Q + K +E K G ++AM +E
Sbjct: 30 HMPGDIIIGALFSVHH-----------QPTVDKVHERKCGAVREQYGIQRVEAMLHTLER 78
Query: 82 INNDSSLLPGVLLGYEIVDVCYISN-NVQPVLYFLAHEDNLLPIQEDY----------SN 130
IN+D +LLP + LG EI D C+ S ++ + F+ D+L+ +E+ S+
Sbjct: 79 INSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFI--RDSLISSEEEEGLVRCVDGSSSS 136
Query: 131 YISR--VVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSAD 188
+ S+ +V VIGP +S + V N L LF +PQI YSA S +L DK F +R PS
Sbjct: 137 FRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDA 196
Query: 189 HHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQN 248
AMV ++ + W ++ + + YG + + A+ ICIA + + Q+
Sbjct: 197 QQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQS 256
Query: 249 MTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGA-VWIASESWAID 307
+ ++L + + K ARVV F +T+ + R G + + S+ WA
Sbjct: 257 F-DKLLKKLTSHLPK-----ARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWA-- 308
Query: 308 PVLHNLTELRHLGTFLGITI--QSVPI------------------PGFSEFREWGPQAGP 347
+++T+ GITI QS + P F EF + Q
Sbjct: 309 -DRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRL 367
Query: 348 PPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDK 407
+ + Y N+ C++ L TL + + V+ ++YS Y + + SL
Sbjct: 368 EGFPQENSKY--NKTCNSSL--TLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYA 423
Query: 408 STC-TKRVVYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQW-QWDRSQNPFQS 464
C + + +LLE + K NFT + I FD GD EI+ + + + + +
Sbjct: 424 GLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYIN 483
Query: 465 VASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQ-KKKPVGIHVCCFECIDCLPG 523
V S+ +LK D W +N I S+CS+ C+ GQ K G CC+ C C
Sbjct: 484 VGSWD--NGELKMDDDEVWSKKSNII-RSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN 540
Query: 524 TFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAI 583
++ DEY C+AC W T C + +L W + IA + A LG L+TL +
Sbjct: 541 EYV---FDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFV 597
Query: 584 LVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTI 643
V+F + TP+V+S+ +C+++L + + Y+ + PK C ++ L +
Sbjct: 598 TVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAM 657
Query: 644 CISCIAVRSFQIVCAF-----KMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGML 698
S + ++ +I K+ ++ PR S + + +AFI + + +++ +
Sbjct: 658 SYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQ-----LVIAFILICIQLGIIVALF 712
Query: 699 ATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNE 758
P ++ ++ CN ++ + LL + +A+ + +P N+NE
Sbjct: 713 IMEPPDIMHDYPSIREVYLI-CNTT-NLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNE 770
Query: 759 AKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLG-YFGPKCYMILF 817
AK+I +M +T+ + F+ Y G I+ + +V ++LG F PK Y+IL
Sbjct: 771 AKYIAFTM---YTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILA 827
Query: 818 YPERNTPAYFNS 829
PERN + F +
Sbjct: 828 KPERNVRSAFTT 839
>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
sapiens]
Length = 877
Score = 226 bits (575), Expect = 9e-59
Identities = 224/855 (26%), Positives = 374/855 (43%), Gaps = 100/855 (11%)
Query: 29 LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSL 88
L G LGGLF +HA +G Q+ K G + ++AM +A++ +N D L
Sbjct: 35 LAGGLTLGGLFPVHA--RGAAGRACGQLK-------KEQGVHRLEAMLYALDRVNADPEL 85
Query: 89 LPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNY---------------IS 133
LPGV LG ++D C S + + L+ L+ + D
Sbjct: 86 LPGVRLGARLLDTC--SRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPE 143
Query: 134 RVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEA 193
RVVAV+G S + VAN L LF +PQI+Y++ + EL D R+ R P + +A
Sbjct: 144 RVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQA 203
Query: 194 MVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARR--DICIAFQETLPTLQPNQNMTS 251
MV ++ WN++ L S YG ++G +++R +CIA +P +P S
Sbjct: 204 MVDIVRALGWNYVSTLASEGNYG-ESGVEAFVQISREAGGVCIAQSIKIPR-EPKPGEFS 261
Query: 252 EERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTG-AVWIASESWA--IDP 308
+ +RL ++ AR +++F+ + + + N TG +W+ S+SW P
Sbjct: 262 KVIRRL------METPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSP 315
Query: 309 VLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLN 368
+L +L ++ +G + I + I GF ++ ++ + N C +
Sbjct: 316 IL-SLEDVA-VGA-ITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSS 372
Query: 369 ATLSFNTILRLSGER------------VVYSVYSAVYAVAHALHSL--LGCDKSTCTKRV 414
T S ++ + +GE V V AVYA+AHALHS+ C T
Sbjct: 373 GTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPA 432
Query: 415 VYPW---QLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQ---WDRSQNPFQSVAS 467
+ P LL+ I V F + F+ GD +I Q+Q S +Q+V
Sbjct: 433 MEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQ 492
Query: 468 YYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLN 527
+ R +++ + W + +P S+CS C G++KK V CC+ C C F
Sbjct: 493 WAETLR--LDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRF-- 548
Query: 528 HTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIF 587
DE+ C+ACP + + T C +V L W LLA LG ++T ++ F
Sbjct: 549 -QVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATF 607
Query: 588 WRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISC 647
R+ TPIVR++G + +++LT + + Y + + V P + C R+ L T+ S
Sbjct: 608 VRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSA 667
Query: 648 IAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYV---SMAFITVLKMVIVVIGMLA-TGLS 703
+ ++ +I F+ R P++ S IT + V+GM+A G
Sbjct: 668 LLTKTNRIYRIFEQGKRSVT--------PPPFISPTSQLVITFSLTSLQVVGMIAWLGAR 719
Query: 704 P--------TTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTN 755
P RT + ++ C+ + SL+ LLL V +A + +P
Sbjct: 720 PPHSVIDYEEQRTVDPEQARGVLKCDMS-DLSLIGCLGYSLLLMVTCTVYAIKARGVPET 778
Query: 756 YNEAKFITLSMTFYFTSSVSLCTFMSAYSG-------VLVTIVDLLVTVLNLLAISLG-Y 807
+NEAK I +M +T+ + F+ + G + + L V++ ++SLG
Sbjct: 779 FNEAKPIGFTM---YTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGML 835
Query: 808 FGPKCYMILFYPERN 822
+ PK Y+ILF+PE+N
Sbjct: 836 YVPKTYVILFHPEQN 850
>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
[Homo sapiens]
Length = 908
Score = 219 bits (559), Expect = 6e-57
Identities = 213/860 (24%), Positives = 376/860 (43%), Gaps = 90/860 (10%)
Query: 31 GDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLP 90
GD +LGGLF +HA + V L+ K G + ++AM +A+++IN D LL
Sbjct: 44 GDIILGGLFPVHAKGERGVPCGELK---------KEKGIHRLEAMLYAIDQINKDPDLLS 94
Query: 91 GVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYI------------SRVVAV 138
+ LG I+D C S + + L L I++D S+ ++ V
Sbjct: 95 NITLGVRILDTC--SRDTYALEQSLTFVQAL--IEKDASDVKCANGDPPIFTKPDKISGV 150
Query: 139 IGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLM 198
IG S + VAN L LF +PQI+Y++ + EL D R+ R P + +AMV ++
Sbjct: 151 IGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIV 210
Query: 199 LHFRWNWIIVLVSSDTYGRDNGQLLGERVARR--DICIAFQETLPTLQPNQNMTSEERQR 256
WN++ L S YG ++G +++R +CIA + +P +P + +R
Sbjct: 211 TALGWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPR-EPRPGEFEKIIKR 268
Query: 257 LVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGA-VWIASESWA--IDPVLHNL 313
L L+ AR V++F+ + + + N +G +WI S+SW I PV
Sbjct: 269 L------LETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE 322
Query: 314 TELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQEC--------DN 365
T L + I GF + A ++ + N C ++
Sbjct: 323 EIAEGAVTILP---KRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNS 379
Query: 366 CLNATLSFNTILRLSG---ERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRV-------- 414
+ I R S E V V AVY++A+ALH++ K C +
Sbjct: 380 HIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNM---HKDLCPGYIGLCPRMST 436
Query: 415 VYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQR 473
+ +LL I VNF + F+ GD +I Q+Q ++ V ++ Q
Sbjct: 437 IDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYK-VIGHWTNQL 495
Query: 474 QLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEY 533
LK ++D+ W +T P S+CS C+ G++KK V CC+ C C N+ DE
Sbjct: 496 HLK-VEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERC---EGYNYQVDEL 551
Query: 534 ECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQT 593
C+ CP ++ + T C ++ LEWH + +A LG ++T ++V F R+ T
Sbjct: 552 SCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDT 611
Query: 594 PIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSF 653
PIVR++G + +++LT + + Y + + + P C R+ L + + ++
Sbjct: 612 PIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTN 671
Query: 654 QIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGM-----LATGLSPTTRT 708
+I F+ + A + ++ + I+V + + V + +
Sbjct: 672 RIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTL 731
Query: 709 DPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTF 768
DP+ + ++ C+ + SL+ + +LL V +A + +P +NEAK I +M
Sbjct: 732 DPEKAR-GVLKCDIS-DLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTM-- 787
Query: 769 YFTSSVSLCTFMSAYSG-------VLVTIVDLLVTVLNLLAISLG-YFGPKCYMILFYPE 820
+T+ + F+ + G + + L V++ ++SLG + PK Y+I+F+PE
Sbjct: 788 -YTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPE 846
Query: 821 RNT---PAYFNSMIQGYTMR 837
+N F +++ TM+
Sbjct: 847 QNVQKRKRSFKAVVTAATMQ 866
>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
[Homo sapiens]
Length = 908
Score = 219 bits (559), Expect = 6e-57
Identities = 213/860 (24%), Positives = 376/860 (43%), Gaps = 90/860 (10%)
Query: 31 GDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLP 90
GD +LGGLF +HA + V L+ K G + ++AM +A+++IN D LL
Sbjct: 44 GDIILGGLFPVHAKGERGVPCGELK---------KEKGIHRLEAMLYAIDQINKDPDLLS 94
Query: 91 GVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYI------------SRVVAV 138
+ LG I+D C S + + L L I++D S+ ++ V
Sbjct: 95 NITLGVRILDTC--SRDTYALEQSLTFVQAL--IEKDASDVKCANGDPPIFTKPDKISGV 150
Query: 139 IGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLM 198
IG S + VAN L LF +PQI+Y++ + EL D R+ R P + +AMV ++
Sbjct: 151 IGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIV 210
Query: 199 LHFRWNWIIVLVSSDTYGRDNGQLLGERVARR--DICIAFQETLPTLQPNQNMTSEERQR 256
WN++ L S YG ++G +++R +CIA + +P +P + +R
Sbjct: 211 TALGWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPR-EPRPGEFEKIIKR 268
Query: 257 LVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGA-VWIASESWA--IDPVLHNL 313
L L+ AR V++F+ + + + N +G +WI S+SW I PV
Sbjct: 269 L------LETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE 322
Query: 314 TELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQEC--------DN 365
T L + I GF + A ++ + N C ++
Sbjct: 323 EIAEGAVTILP---KRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNS 379
Query: 366 CLNATLSFNTILRLSG---ERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRV-------- 414
+ I R S E V V AVY++A+ALH++ K C +
Sbjct: 380 HIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNM---HKDLCPGYIGLCPRMST 436
Query: 415 VYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQR 473
+ +LL I VNF + F+ GD +I Q+Q ++ V ++ Q
Sbjct: 437 IDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYK-VIGHWTNQL 495
Query: 474 QLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEY 533
LK ++D+ W +T P S+CS C+ G++KK V CC+ C C N+ DE
Sbjct: 496 HLK-VEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERC---EGYNYQVDEL 551
Query: 534 ECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQT 593
C+ CP ++ + T C ++ LEWH + +A LG ++T ++V F R+ T
Sbjct: 552 SCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDT 611
Query: 594 PIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSF 653
PIVR++G + +++LT + + Y + + + P C R+ L + + ++
Sbjct: 612 PIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTN 671
Query: 654 QIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGM-----LATGLSPTTRT 708
+I F+ + A + ++ + I+V + + V + +
Sbjct: 672 RIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTL 731
Query: 709 DPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTF 768
DP+ + ++ C+ + SL+ + +LL V +A + +P +NEAK I +M
Sbjct: 732 DPEKAR-GVLKCDIS-DLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTM-- 787
Query: 769 YFTSSVSLCTFMSAYSG-------VLVTIVDLLVTVLNLLAISLG-YFGPKCYMILFYPE 820
+T+ + F+ + G + + L V++ ++SLG + PK Y+I+F+PE
Sbjct: 788 -YTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPE 846
Query: 821 RNT---PAYFNSMIQGYTMR 837
+N F +++ TM+
Sbjct: 847 QNVQKRKRSFKAVVTAATMQ 866
>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
Length = 906
Score = 218 bits (555), Expect = 2e-56
Identities = 215/863 (24%), Positives = 384/863 (44%), Gaps = 113/863 (13%)
Query: 29 LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKV-IGYNLMQAMRFAVEEINNDSS 87
+ GD ++G LFS+H +VP K E++ G ++AM +++IN D
Sbjct: 41 MDGDVIIGALFSVHHQPPAE------KVPERKCGEIREQYGIQRVEAMFHTLDKINADPV 94
Query: 88 LLPGVLLGYEIVDVCYISN-NVQPVLYFLAHEDNLLPIQEDYSNYISR------------ 134
LLP + LG EI D C+ S+ ++ + F+ D+L+ I+++ I+R
Sbjct: 95 LLPNITLGSEIRDSCWHSSVALEQSIEFI--RDSLISIRDEKDG-INRCLPDGQSLPPGR 151
Query: 135 ----VVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHH 190
+ VIGP +S + V N L LF +PQI YSA S +L DK + LR PS
Sbjct: 152 TKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQ 211
Query: 191 IEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMT 250
AM+ ++ + W ++ + + YG E A+ +CIA + + + N
Sbjct: 212 ARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYS---NAGEK 268
Query: 251 SEERQRLVTIVDKLQQST--ARVVVVFSPDLTLYHFFNEVLRQNFTGAV-WIASESWAID 307
S +R ++ KL++ ARVVV F +T+ + + R G I S+ WA
Sbjct: 269 SFDR-----LLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADR 323
Query: 308 PVLHNLTELRHLGTFLGITI--QSVPIPGFSEF-----------REWGPQAGPPPLS--- 351
+ E+ G GITI QS + F ++ W P+
Sbjct: 324 DEVIEGYEVEANG---GITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRL 380
Query: 352 --RTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHAL----HSLLGC 405
++ + C N +L N + + + V +A+YA+AH L H+L
Sbjct: 381 PGHLLENPNFKRICTG--NESLEENYVQ----DSKMGFVINAIYAMAHGLQNMHHALCPG 434
Query: 406 DKSTC-TKRVVYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQW-DRSQNPF 462
C + + +LL+ + K +F + +++FD +GD +I+ Q+ + ++ +
Sbjct: 435 HVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDY 494
Query: 463 QSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKK-PVGIHVCCFECIDCL 521
V +++ + NI D + + S+CS+ C GQ K G CC+ C C
Sbjct: 495 VHVGTWH---EGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACK 551
Query: 522 PGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTL 581
++ +DE+ C+AC W T C + +LEW +I + LG L TL
Sbjct: 552 ENEYV---QDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTL 608
Query: 582 AILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCF 641
+ +IF + TP+V+S+ +C+++L + + Y+ + P ++C ++ L L
Sbjct: 609 FVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSS 668
Query: 642 TICISCIAVRSFQIVCAF-----KMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIG 696
+C S + ++ +I K+ +R PR S W + V +A I + + +V+
Sbjct: 669 AMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQ-----VIIASILISVQLTLVVT 723
Query: 697 MLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFS---------FAY 747
++ +P P ++ S Y L+ NTS +++ +G++ +A+
Sbjct: 724 LII--------MEPPMPILSYPSIKEVY---LICNTSNLGVVAPLGYNGLLIMSCTYYAF 772
Query: 748 MGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLG- 806
+ +P N+NEAK+I +M +T+ + F+ Y G I+ V + ++LG
Sbjct: 773 KTRNVPANFNEAKYIAFTM---YTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGC 829
Query: 807 YFGPKCYMILFYPERNTPAYFNS 829
F PK Y+I+ PERN + F +
Sbjct: 830 MFTPKMYIIIAKPERNVRSAFTT 852
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 218 bits (555), Expect = 2e-56
Identities = 215/863 (24%), Positives = 384/863 (44%), Gaps = 113/863 (13%)
Query: 29 LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKV-IGYNLMQAMRFAVEEINNDSS 87
+ GD ++G LFS+H +VP K E++ G ++AM +++IN D
Sbjct: 41 MDGDVIIGALFSVHHQPPAE------KVPERKCGEIREQYGIQRVEAMFHTLDKINADPV 94
Query: 88 LLPGVLLGYEIVDVCYISN-NVQPVLYFLAHEDNLLPIQEDYSNYISR------------ 134
LLP + LG EI D C+ S+ ++ + F+ D+L+ I+++ I+R
Sbjct: 95 LLPNITLGSEIRDSCWHSSVALEQSIEFI--RDSLISIRDEKDG-INRCLPDGQSLPPGR 151
Query: 135 ----VVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHH 190
+ VIGP +S + V N L LF +PQI YSA S +L DK + LR PS
Sbjct: 152 TKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQ 211
Query: 191 IEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMT 250
AM+ ++ + W ++ + + YG E A+ +CIA + + + N
Sbjct: 212 ARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYS---NAGEK 268
Query: 251 SEERQRLVTIVDKLQQST--ARVVVVFSPDLTLYHFFNEVLRQNFTGAV-WIASESWAID 307
S +R ++ KL++ ARVVV F +T+ + + R G I S+ WA
Sbjct: 269 SFDR-----LLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADR 323
Query: 308 PVLHNLTELRHLGTFLGITI--QSVPIPGFSEF-----------REWGPQAGPPPLS--- 351
+ E+ G GITI QS + F ++ W P+
Sbjct: 324 DEVIEGYEVEANG---GITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRL 380
Query: 352 --RTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHAL----HSLLGC 405
++ + C N +L N + + + V +A+YA+AH L H+L
Sbjct: 381 PGHLLENPNFKRICTG--NESLEENYVQ----DSKMGFVINAIYAMAHGLQNMHHALCPG 434
Query: 406 DKSTC-TKRVVYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQW-DRSQNPF 462
C + + +LL+ + K +F + +++FD +GD +I+ Q+ + ++ +
Sbjct: 435 HVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDY 494
Query: 463 QSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKK-PVGIHVCCFECIDCL 521
V +++ + NI D + + S+CS+ C GQ K G CC+ C C
Sbjct: 495 VHVGTWH---EGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACK 551
Query: 522 PGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTL 581
++ +DE+ C+AC W T C + +LEW +I + LG L TL
Sbjct: 552 ENEYV---QDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTL 608
Query: 582 AILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCF 641
+ +IF + TP+V+S+ +C+++L + + Y+ + P ++C ++ L L
Sbjct: 609 FVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSS 668
Query: 642 TICISCIAVRSFQIVCAF-----KMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIG 696
+C S + ++ +I K+ +R PR S W + V +A I + + +V+
Sbjct: 669 AMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQ-----VIIASILISVQLTLVVT 723
Query: 697 MLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFS---------FAY 747
++ +P P ++ S Y L+ NTS +++ +G++ +A+
Sbjct: 724 LII--------MEPPMPILSYPSIKEVY---LICNTSNLGVVAPLGYNGLLIMSCTYYAF 772
Query: 748 MGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLG- 806
+ +P N+NEAK+I +M +T+ + F+ Y G I+ V + ++LG
Sbjct: 773 KTRNVPANFNEAKYIAFTM---YTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGC 829
Query: 807 YFGPKCYMILFYPERNTPAYFNS 829
F PK Y+I+ PERN + F +
Sbjct: 830 MFTPKMYIIIAKPERNVRSAFTT 852
>gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]
Length = 324
Score = 106 bits (265), Expect = 8e-23
Identities = 72/195 (36%), Positives = 100/195 (51%), Gaps = 13/195 (6%)
Query: 26 DFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMC-KEYEVKVIGYNLMQAMRFAVEEINN 84
DF LPGDYLL GLF LH+ + H +V +C + GY+L QAMR VEEINN
Sbjct: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRP--EVTLCDRSCSFNEHGYHLFQAMRLGVEEINN 88
Query: 85 DSSLLPGVLLGYEIVDVCYISNNVQPVLYFLA-HEDNLLPIQEDYSNYISRVVAVIGPDN 143
++LLP + LGY++ DVC S NV L L+ + + +Q D +Y V+AVIGPD+
Sbjct: 89 STALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDS 148
Query: 144 SESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRW 203
+ T A LS FL+P + E KV F T D+ ++ + W
Sbjct: 149 TNRAATTAALLSPFLVPMLL------EQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDW 202
Query: 204 N---WIIVLVSSDTY 215
N W ++ S T+
Sbjct: 203 NGPKWTFTVLGSSTW 217
Score = 82.8 bits (203), Expect = 1e-15
Identities = 50/138 (36%), Positives = 68/138 (49%), Gaps = 7/138 (5%)
Query: 420 LLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVAS--YYPLQRQLKN 477
LLE+I KV+F L + F+ D I+ W W+ + F + S + P+Q + N
Sbjct: 167 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNI-N 225
Query: 478 IQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYE-CQ 536
I WH +N +P S+CS C G ++ G H CCFEC+ C GTFLN + CQ
Sbjct: 226 ETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSATWVRTCQ 285
Query: 537 AC---PNNEWSYQSETSC 551
PN S S TSC
Sbjct: 286 RTTTRPNVSPSACSSTSC 303
>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
sapiens]
Length = 254
Score = 63.2 bits (152), Expect = 1e-09
Identities = 52/216 (24%), Positives = 104/216 (48%), Gaps = 18/216 (8%)
Query: 620 VYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPY 679
+++ P + C R+ F++C S + ++ +I F A R + R+ P
Sbjct: 4 IFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGA----REGAQRPRFISPA 59
Query: 680 VSMAFITVL---KMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRN-SLLFNTSLD 735
+A L +++IVV ++ T P+ ++ + CN +R+ S+L + + +
Sbjct: 60 SQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCN--HRDASMLGSLAYN 117
Query: 736 LLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAY----SGVLVTIV 791
+LL + +A+ ++ P N+NEAKFI +M +T+ + F+ + S V
Sbjct: 118 VLLIALCTLYAFKTRKCPENFNEAKFIGFTM---YTTCIIWLAFLPIFYVTSSDYRVQTT 174
Query: 792 DLLVTVLNLLAISLG-YFGPKCYMILFYPERNTPAY 826
+ V+V ++ LG F PK ++ILF P++N ++
Sbjct: 175 TMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSH 210
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 19/181 (10%)
Query: 56 VPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFL 115
+P+ KE IG ++ A+ A+E+I N+S L P L + D +N + + F
Sbjct: 62 MPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRP-YFLDLRLYDT--ECDNAKGLKAFY 118
Query: 116 AHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKV 175
D Y + V G +A L + L Q++++A + L DK
Sbjct: 119 -----------DAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKK 167
Query: 176 RFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVS-----SDTYGRDNGQLLGERVARR 230
++P RT PS + A+++L+ H++W + L S+ G L GE +
Sbjct: 168 KYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEIS 227
Query: 231 D 231
D
Sbjct: 228 D 228
>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
precursor [Homo sapiens]
Length = 899
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/205 (24%), Positives = 81/205 (39%), Gaps = 15/205 (7%)
Query: 68 GYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQED 127
G A+ A+E++N+ +LP L D LY L + D PI+
Sbjct: 123 GQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYND---PIK-- 177
Query: 128 YSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSA 187
++ P S VA ++ L ++Y + S L ++ RFP RT PSA
Sbjct: 178 ---------IILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSA 228
Query: 188 DHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQ 247
H V+L + W I + + L ERV I I F+++ + P
Sbjct: 229 TLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFS-DPAV 287
Query: 248 NMTSEERQRLVTIVDKLQQSTARVV 272
+ + +RQ IV ++ AR V
Sbjct: 288 PVKNLKRQDARIIVGLFYETEARKV 312
>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
precursor [Homo sapiens]
Length = 844
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/205 (24%), Positives = 81/205 (39%), Gaps = 15/205 (7%)
Query: 68 GYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQED 127
G A+ A+E++N+ +LP L D LY L + D PI+
Sbjct: 68 GQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYND---PIK-- 122
Query: 128 YSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSA 187
++ P S VA ++ L ++Y + S L ++ RFP RT PSA
Sbjct: 123 ---------IILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSA 173
Query: 188 DHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQ 247
H V+L + W I + + L ERV I I F+++ + P
Sbjct: 174 TLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFS-DPAV 232
Query: 248 NMTSEERQRLVTIVDKLQQSTARVV 272
+ + +RQ IV ++ AR V
Sbjct: 233 PVKNLKRQDARIIVGLFYETEARKV 257
>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
precursor [Homo sapiens]
Length = 961
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/205 (24%), Positives = 81/205 (39%), Gaps = 15/205 (7%)
Query: 68 GYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQED 127
G A+ A+E++N+ +LP L D LY L + D PI+
Sbjct: 185 GQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYND---PIK-- 239
Query: 128 YSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSA 187
++ P S VA ++ L ++Y + S L ++ RFP RT PSA
Sbjct: 240 ---------IILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSA 290
Query: 188 DHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQ 247
H V+L + W I + + L ERV I I F+++ + P
Sbjct: 291 TLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFS-DPAV 349
Query: 248 NMTSEERQRLVTIVDKLQQSTARVV 272
+ + +RQ IV ++ AR V
Sbjct: 350 PVKNLKRQDARIIVGLFYETEARKV 374
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/212 (20%), Positives = 83/212 (39%), Gaps = 39/212 (18%)
Query: 141 PDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLH 200
P++ + V+ + +P + + DK + LRT P H ++M
Sbjct: 98 PNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRV 157
Query: 201 FRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEE------- 253
+ WN II+LVS D GR A Q+ L TL + +E+
Sbjct: 158 YSWNHIILLVSDDHEGR-----------------AAQKRLETLLEERESKAEKVLQFDPG 200
Query: 254 RQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGA--VWIASE--------S 303
+ + ++ + ++ ARV+++ + + + N TG+ VW+ E
Sbjct: 201 TKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALR 260
Query: 304 WAIDPVL-----HNLTELRHLGTFLGITIQSV 330
+A D +L + E H+ +G+ Q+V
Sbjct: 261 YAPDGILGLQLINGKNESAHISDAVGVVAQAV 292
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/212 (20%), Positives = 83/212 (39%), Gaps = 39/212 (18%)
Query: 141 PDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLH 200
P++ + V+ + +P + + DK + LRT P H ++M
Sbjct: 98 PNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRV 157
Query: 201 FRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEE------- 253
+ WN II+LVS D GR A Q+ L TL + +E+
Sbjct: 158 YSWNHIILLVSDDHEGR-----------------AAQKRLETLLEERESKAEKVLQFDPG 200
Query: 254 RQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGA--VWIASE--------S 303
+ + ++ + ++ ARV+++ + + + N TG+ VW+ E
Sbjct: 201 TKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALR 260
Query: 304 WAIDPVL-----HNLTELRHLGTFLGITIQSV 330
+A D +L + E H+ +G+ Q+V
Sbjct: 261 YAPDGILGLQLINGKNESAHISDAVGVVAQAV 292
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/212 (20%), Positives = 83/212 (39%), Gaps = 39/212 (18%)
Query: 141 PDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLH 200
P++ + V+ + +P + + DK + LRT P H ++M
Sbjct: 98 PNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRV 157
Query: 201 FRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEE------- 253
+ WN II+LVS D GR A Q+ L TL + +E+
Sbjct: 158 YSWNHIILLVSDDHEGR-----------------AAQKRLETLLEERESKAEKVLQFDPG 200
Query: 254 RQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGA--VWIASE--------S 303
+ + ++ + ++ ARV+++ + + + N TG+ VW+ E
Sbjct: 201 TKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALR 260
Query: 304 WAIDPVL-----HNLTELRHLGTFLGITIQSV 330
+A D +L + E H+ +G+ Q+V
Sbjct: 261 YAPDGILGLQLINGKNESAHISDAVGVVAQAV 292
>gi|40217833 G protein-coupled receptor family C, group 5, member C
isoform b [Homo sapiens]
Length = 453
Score = 39.3 bits (90), Expect = 0.015
Identities = 28/92 (30%), Positives = 41/92 (44%), Gaps = 4/92 (4%)
Query: 567 IAVALLAALGFLSTLAILVIFWRHF---QTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVG 623
I + +A G ++T + +I Q RS G F +L L + +V V
Sbjct: 63 IVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVV- 121
Query: 624 PPKVSTCLCRQALFPLCFTICISCIAVRSFQI 655
P STC R+ LF + F IC SC+A F +
Sbjct: 122 KPDFSTCASRRFLFGVLFAICFSCLAAHVFAL 153
>gi|40217831 G protein-coupled receptor family C, group 5, member C
isoform a [Homo sapiens]
Length = 486
Score = 39.3 bits (90), Expect = 0.015
Identities = 28/92 (30%), Positives = 41/92 (44%), Gaps = 4/92 (4%)
Query: 567 IAVALLAALGFLSTLAILVIFWRHF---QTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVG 623
I + +A G ++T + +I Q RS G F +L L + +V V
Sbjct: 96 IVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVV- 154
Query: 624 PPKVSTCLCRQALFPLCFTICISCIAVRSFQI 655
P STC R+ LF + F IC SC+A F +
Sbjct: 155 KPDFSTCASRRFLFGVLFAICFSCLAAHVFAL 186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,079,536
Number of Sequences: 37866
Number of extensions: 1434471
Number of successful extensions: 4160
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 3974
Number of HSP's gapped (non-prelim): 79
length of query: 839
length of database: 18,247,518
effective HSP length: 111
effective length of query: 728
effective length of database: 14,044,392
effective search space: 10224317376
effective search space used: 10224317376
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.